Objective: 

To describe the prevalence of exercise in a national sample of veterans with multiple sclerosis (MS) and the association of exercise with quality of life, including physical health, mental health, and participation restriction.

Design: 

Cross-sectional cohort study linking computerized medical records to mailed survey data from 1999.

Setting: 

Veterans Health Administration.

Participants: 

Veterans with MS (N=2995; 86.5% men) who received services in the Veterans Health Administration and returned survey questionnaires.

Interventions: 

Not applicable.

Main Outcome Measures: 

Demographic information, Veteran RAND 36-Item Health Survey (VR-36), self-reported exercise frequency.

Results: 

Among all survey respondents with MS, only 28.6% (95% confidence interval, 26.9–30.2) endorsed any exercise. In adjusted logistic regression, exercise was associated with younger age, more education, living alone, lower levels of bodily pain, and higher body mass index. After adjusting for demographic variables and medical comorbidities, exercise was associated with better physical and mental health. People who exercised reported they had better social functioning and better role functioning (participation in life despite physical and emotional difficulties).

Conclusions: 

Exercise in veterans with MS is uncommon. In the context of chronic illness care, the identification of exercise patterns and promotion of physical activity may represent an important opportunity to improve mental health and quality of life among people with MS. Intervention should address factors associated with lower rates of exercise including age, education, and pain.